AntiCancer Inc.
Recombinant L-Methionine-g-Lyase

 
rMETase is a selective-anti-tumor agent
Figure 1.  Efficacy of rMETase on growth of human colon tumors
HCT 15 and HT 29 in nude mice.

rMETase (5 or 10 units/g every 8 h) was administered by i.p. injection in nude mice with human colon tumor HCT 15 (A) and HT 29 (B) growing s.c. The efficacy was evaluated by tumor weight.  Bars, SD [5].
Figure 2.  Antitumor efficacy of rMETase in combination with 5-FU
against Lewis lung carcinoma.
Antitumor efficacy of the combination of rMETase and 5-FU on the Lewis lung carcinoma.  BDF1 mice bearing the Lewis lung carcinoma were treated with normal saline (NS) control, rMETase (600 units × 2/day × 12), 5-FU (13.2 mg/mg × 5), or the combination of rMETase and 5-FU.  The tumor growth inhibition (A) and survival rate (B) are shown [4].
Markers: NS (
), rMETase (∆), 5-FU (□), combination of rMETase and 5-FU ().