rMETase is a selective-anti-tumor agent
Figure 1. Efficacy of rMETase on growth of human colon tumors
HCT 15 and HT 29 in nude mice.
rMETase (5 or 10 units/g every 8 h) was administered by i.p. injection in nude mice with human colon tumor HCT 15 (A) and HT 29 (B) growing s.c. The efficacy was evaluated by tumor weight. Bars, SD .
Figure 2. Antitumor efficacy of rMETase in combination with 5-FU
against Lewis lung carcinoma.
Antitumor efficacy of the combination of rMETase and 5-FU on the Lewis lung carcinoma. BDF1 mice bearing the Lewis lung carcinoma were treated with normal saline (NS) control, rMETase (600 units × 2/day × 12), 5-FU (13.2 mg/mg × 5), or the combination of rMETase and 5-FU. The tumor growth inhibition (A) and survival rate (B) are shown .
Markers: NS (∘), rMETase (∆), 5-FU (□), combination of rMETase and 5-FU (∙).