AntiCancer Inc.
Recombinant L-Methionine-g-Lyase

Ordering Information
AntiCancer, Inc. 7917 Ostrow Street, San Diego, CA 92111 USA 
Telephone: (858)654-2555;  E-mail:
US Patent Nos. 6,231,854; 5,888,506; 5,690.929; 5,891,704; 7,329,516; 8,465,734; 7,799,549. Japan Patent No. 2,930,723. Europe Patent Nos. 668,933; 1,287,830.
Australia Patent No. 687,768. Canada Patent No. 2,149,776. China Patent Nos. ZL200480017595.6; ZL200580015792.9.
Major Publications
1. Hoffman, R.M., Jacobsen, S.J., and Erbe, R.W.  Reversion to methionine independence in
     simian virus 40-transformed human and malignant rat fibroblasts is associated with altered 
     ploidy and altered properties of transformation. Proc. Natl. Acad. Sci. USA 76, 1313-1317, 1979.
2. Tan, Y., Xu, M., Tan, X-Z., Tan, X-Y., Wang., X., Saikawa, Y., Nagahama, T., Sun, X., Lenz, M., and
     Hoffman, R.M.  Overexpression and large-scale production of recombinant l-methionine-
g-mercaptomethane-lyase for novel anticancer therapy.  Protein Expression and Purification 9, 233-
     245, 1997.
3. Tan, Y., Sun, X., Xu, M., An, Z., Tan, X-Z., Tan, X-Y., Han, Q., Miljkovic, D.A., Yang, M., and Hoffman,
     R.M. Polyethylene glycol conjugation of recombinant methioninase for cancer therapy.  Protein
     Expression and Purification 12, 45-52, 1998.
4. Yoshioka, T., Wada, T., Uchida, N., Maki, H., Yoshida, H., Ide, N., Kasai, H., Hojo, K., Shono, K.,
    Maekawa, R., Yagi, S., Hoffman, R.M., and Sugita, K.  Anticancer efficacy in vivo and in vitro, synergy
    with 5-fluorouracil, and safety of recombinant methioninase.  Cancer Research 58, 2583-2587, 1998.
5. Tan, Y., Sun, X., Xu, M., Tan, X-Z., Sasson, A., Rashidi, B., Han, Q., Tan, X-Y., Wang, X., An, Z., Sun,  F-X.,
    and Hoffman, R.M.  Efficacy of recombinant methioninase in combination with cisplatin on human
    colon tumors in nude mice.  Clinical Cancer Research 5, 2157-2163, 1999.
6. Sun, X., Yang, Z., Li, S., Tan, Y., Zhang, N., Wang, X., Yagi, S., Yoshioka, T., Takimoto, A., Mitsushima, K.,
    Suginaka, A., Frenkel, E.P., and Hoffman, R.M.  In vivo efficacy of recombinant methioninase is
    enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5
ยข phosphate
    supplementation.  Cancer Research 63, 8377-8383, 2003.
7. Yano, S., Li, S., Han, Q., Tan, Y., Bouvet, M., Fujiwara, T., and Hoffman, R.M.  Selective methioninase-
    induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity. 
    Oncotarget 5, 8729-8736, 2014.
8. Hoffman, R.M.  Development of recombinant methioninase to target the general cancer-specific
    metabolic defect of methionine dependence: a 40-year odyssey.  Expert Opin. Biol. Ther. 15, 21-31, 2015.